Discovery and initial SAR of pyrimidin-4-yl-1H-imidazole derivatives with antiproliferative activity against melanoma cell lines.

Abstract

The synthesis of a novel series of pyrimidin-4-yl-1H-imidazol-2-yl derivatives 7, 8, 9 and their antiproliferative activities against A375P human melanoma cell line and WM3629 cell line were described. Most compounds showed superior antiproliferative activities compared to Sorafenib, the well-known RAF inhibitor. Among them, 7a exhibited potent activities… (More)
DOI: 10.1016/j.bmcl.2010.01.064

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@article{Lee2010DiscoveryAI, title={Discovery and initial SAR of pyrimidin-4-yl-1H-imidazole derivatives with antiproliferative activity against melanoma cell lines.}, author={Junghun Lee and Hwan Kim and Hana G Yu and Jae Yoon Chung and Chang-Hyun Oh and Kyung Ho Yoo and Taebo Sim and J Hun Hah}, journal={Bioorganic & medicinal chemistry letters}, year={2010}, volume={20 5}, pages={1573-7} }