Discovery and identification of sequence polymorphisms and mutations with MALDI-TOF MS.

Abstract

Matrix-assisted laser desorption ionization (MALDI) time-of-flight (TOF) mass spectrometry (MS) has become a widely used technology for the detection of nucleic acids. In this chapter we introduce its use for the discovery of novel sequence polymorphisms and the identification of known DNA changes. We first provide a brief overview about MALDI-TOF MS… (More)

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