Discovery and functional prioritization of Parkinson’s disease candidate genes from large-scale whole exome sequencing


Whole-exome sequencing (WES) has been successful in identifying genes that cause familial Parkinson’s disease (PD). However, until now this approach has not been deployed to study large cohorts of unrelated participants. To discover rare PD susceptibility variants, we performed WES in 1148 unrelated cases and 503 control participants. Candidate genes were… (More)
DOI: 10.1186/s13059-017-1147-9


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