Discovery and evaluation of asymmetrical monocarbonyl analogs of curcumin as anti-inflammatory agents


Sepsis is a systemic inflammatory response syndrome and is mainly caused by lipopolysaccharides (LPS) - a component of the cell walls of gram-negative bacteria, via toll-like receptor 4-mitogen-activated protein kinases/nuclear factor-kappa B-dependent proinflammatory signaling pathway. Here, we synthesized 26 asymmetric monocarbonyl analogs of curcumin and… (More)
DOI: 10.2147/DDDT.S58168


8 Figures and Tables