Discovery and development of the monobactams.

  title={Discovery and development of the monobactams.},
  author={Richard B. Sykes and Daniel P. Bonner},
  journal={Reviews of infectious diseases},
  volume={7 Suppl 4},
A novel procedure designed to detect naturally occurring beta-lactam-containing molecules led to isolation of the monobactams - structurally unique, bacterially produced, monocyclic beta-lactam antibiotics. Although none of these monobactams exhibited impressive antimicrobial activity, side-chain variation - as with the penicillins and cephalosporins - resulted in potently active compounds. Aztreonam was chosen from hundreds of compounds for extended laboratory studies. In addition to a unique… CONTINUE READING

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