Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer.

Abstract

Certain guanine-rich (G-rich) DNA and RNA molecules can associate intermolecularly or intramolecularly to form four stranded or "quadruplex" structures, which have unusual biophysical and biological properties. Several synthetic G-rich quadruplex-forming oligodeoxynucleotides have recently been investigated as therapeutic agents for various human diseases… (More)
DOI: 10.1016/j.yexmp.2009.01.004

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