Discovery and development of natural product oridonin-inspired anticancer agents.

@article{Ding2016DiscoveryAD,
  title={Discovery and development of natural product oridonin-inspired anticancer agents.},
  author={Ye Ding and Chunyong Ding and Na Ye and Zhiqing Liu and Eric A Wold and Haiying Chen and Christopher T Wild and Qiang Shen and Jia Zhou},
  journal={European journal of medicinal chemistry},
  year={2016},
  volume={122},
  pages={
          102-117
        }
}
Natural products have historically been, and continue to be, an invaluable source for the discovery of various therapeutic agents. Oridonin, a natural diterpenoid widely applied in traditional Chinese medicines, exhibits a broad range of biological effects including anticancer and anti-inflammatory activities. To further improve its potency, aqueous solubility and bioavailability, the oridonin template serves as an exciting platform for drug discovery to yield better candidates with unique… Expand
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