Discovery and development of folic-acid-based receptor targeting for imaging and therapy of cancer and inflammatory diseases.

@article{Low2008DiscoveryAD,
  title={Discovery and development of folic-acid-based receptor targeting for imaging and therapy of cancer and inflammatory diseases.},
  author={Philip S Low and Walter A Henne and Derek D Doorneweerd},
  journal={Accounts of chemical research},
  year={2008},
  volume={41 1},
  pages={120-9}
}
In order to avoid the toxicities associated with prescription drug use today, we have explored novel methods for delivering drugs selectively to pathologic cells, thereby avoiding the collateral damage that accompanies their uptake by healthy cells. In this Account, we describe our quest for the ideal targeted therapeutic agent. This effort began with a search for ligands that would bind selectively to pathologic cells, displaying no affinity for healthy cells. After identification of an… CONTINUE READING

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