Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5)

@article{Huard2015DiscoveryAC,
  title={Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5)},
  author={Kim Huard and Janice Brown and Jessica C. Jones and Shawn Cabral and Kentaro Futatsugi and Matthew F Gorgoglione and Adhiraj Lanba and Nicholas B. Vera and Yimin Zhu and Qingyun Yan and Yingjiang Zhou and C{\'e}cile Vernochet and Keith A. Riccardi and Angela C Wolford and David Pirman and Mark Niosi and Gary Erik Aspnes and Michael Herr and Nathan E. Genung and Thomas V. Magee and Daniel P. Uccello and Paula M. Loria and Li juan Di and James R. Gosset and David Hepworth and Timothy P Rolph and Jeffrey A. Pfefferkorn and Derek M. Erion},
  journal={Scientific Reports},
  year={2015},
  volume={5}
}
  • Kim Huard, Janice Brown, +25 authors Derek M. Erion
  • Published 2015
  • Biology, Medicine
  • Scientific Reports
  • Citrate is a key regulatory metabolic intermediate as it facilitates the integration of the glycolysis and lipid synthesis pathways. Inhibition of hepatic extracellular citrate uptake, by blocking the sodium-coupled citrate transporter (NaCT or SLC13A5), has been suggested as a potential therapeutic approach to treat metabolic disorders. NaCT transports citrate from the blood into the cell coupled to the transport of sodium ions. The studies herein report the identification and characterization… CONTINUE READING

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