Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine.

@article{Williams2014DiscoveryAC,
  title={Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine.},
  author={B Blairanne Williams and Andrew H. Van Benschoten and Peter Cimermancic and Mohamed S Donia and Michael Zimmermann and Mao Taketani and Atsushi Ishihara and Purna C. Kashyap and James S Fraser and Michael A. Fischbach},
  journal={Cell host & microbe},
  year={2014},
  volume={16 4},
  pages={495-503}
}
Several recent studies describe the influence of the gut microbiota on host brain and behavior. However, the mechanisms responsible for microbiota-nervous system interactions are largely unknown. Using a combination of genetics, biochemistry, and crystallography, we identify and characterize two phylogenetically distinct enzymes found in the human microbiome that decarboxylate tryptophan to form the β-arylamine neurotransmitter tryptamine. Although this enzymatic activity is exceedingly rare… CONTINUE READING

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Discovery and Characterization of Gut Microbiota Decarboxylases that Can Produce the Neurotransmitter Tryptamine

Williams
Cell Host & Microbe (2014), • 2014

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