Discovery and characterization of a marine bacterial SAM-dependent chlorinase.

  title={Discovery and characterization of a marine bacterial SAM-dependent chlorinase.},
  author={Alessandra S Eust{\'a}quio and Florence Pojer and Joseph P Noel and Bradley S Moore},
  journal={Nature chemical biology},
  volume={4 1},
Halogen atom incorporation into a scaffold of bioactive compounds often amplifies biological activity, as is the case for the anticancer agent salinosporamide A (1), a chlorinated natural product from the marine bacterium Salinispora tropica. Significant effort in understanding enzymatic chlorination shows that oxidative routes predominate to form reactive electrophilic or radical chlorine species. Here we report the genetic, biochemical and structural characterization of the chlorinase SalL… CONTINUE READING
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