Discovery and biological characterization of 1-(1H-indol-3-yl)-9H-pyrido[3,4-b]indole as an aryl hydrocarbon receptor activator generated by photoactivation of tryptophan by sunlight.

@article{DianiMoore2011DiscoveryAB,
  title={Discovery and biological characterization of 1-(1H-indol-3-yl)-9H-pyrido[3,4-b]indole as an aryl hydrocarbon receptor activator generated by photoactivation of tryptophan by sunlight.},
  author={Silvia Diani-Moore and Yuliang Ma and Erin M Labitzke and Hui Tao and J David Warren and Jared L Anderson and Qiuying Chen and Steven S. Gross and Arleen B. Rifkind},
  journal={Chemico-biological interactions},
  year={2011},
  volume={193 2},
  pages={119-28}
}
Activation of the aryl hydrocarbon receptor (AHR) by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is required for AHR dependent transcriptional activation and TCDD toxicity. We previously reported that aqueous tryptophan exposed to sunlight through window glass (aTRP) contains multiple photoproducts, including the well characterized 6-formylindolo[3,2-b]carbazole (FICZ), capable of activating the AHR and inducing CYP1A and CYP1A-mediated enzyme activities. We report here the isolation from aTRP… CONTINUE READING