Discovery and analysis of the first endogenous lentivirus.

  title={Discovery and analysis of the first endogenous lentivirus.},
  author={Aris Katzourakis and Michael Tristem and Oliver G. Pybus and Robert James Gifford},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={104 15},
The lentiviruses are associated with a wide range of chronic diseases in mammals. These include immunodeficiencies (such as HIV/AIDS in humans), malignancies, and lymphatic and neurological disorders in primates, felids, and a variety of wild and domesticated ungulates. Evolutionary analyses of the genomic sequences of modern-day lentiviruses have suggested a relatively recent date for their emergence, but the failure to identify any endogenous, vertically transmitted examples has meant that… CONTINUE READING
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