Discovery and Refinement of Loci Associated with Lipid Levels

  title={Discovery and Refinement of Loci Associated with Lipid Levels},
  author={Cristen J. Willer and Ellen M. Schmidt and Sebanti Sengupta and Gina Marie Peloso and Stefan Gustafsson and Stavroula Kanoni and Andrea Ganna and Jin Hong Chen and Martin L Buchkovich and Samia Mora and Jacques S. Beckmann and Jennifer Bragg-Gresham and H Chang and Ayşe Demirkan and Heleen den Hertog and Ron Do and Louise A. Donnelly and Georg B. Ehret and T{\~o}nu Esko and Mary F Feitosa and Teresa Ferreira and Krista Fischer and Pierre Fontanillas and Ross Fraser and Daniel F. Freitag and Deepti Gurdasani and Kauko Heikkil{\"a} and Elina Hypp{\"o}nen and Aaron Isaacs and Anne U. Jackson and {\AA}sa Johansson and Toby Johnson and Marika Kaakinen and Johannes Kettunen and Marcus E. Kleber and Xiaohui Li and Jian’an Luan and Leo-Pekka Lyytik{\"a}inen and Patrik K E Magnusson and Massimo Mangino and Evelin Mihailov and May E. Montasser and Martina M{\"u}ller-Nurasyid and Ilja M. Nolte and Jeffrey R. O’Connell and Cameron D. Palmer and Markus Perola and Ann-Kristin Petersen and Serena Sanna and Richa Saxena and Susan K. Service and Sonia Shah and Dmitry Shungin and Carlo Sidore and Ci Song and Rona J. Strawbridge and Ida Surakka and Toshiko Tanaka and Tanya M. Teslovich and Gudmar Thorleifsson and Evita G. Van den Herik and Benjamin F. Voight and Kelly A. Volcik and Lindsay L. Waite and Andrew Wong and Ying Wu and Weihua Zhang and Devin Absher and Gershim Asiki and In{\^e}s Barroso and Latonya F. Been and Jennifer Lynn Bolton and Lori L. Bonnycastle and Paolo Brambilla and Mary Susan Burnett and Giancarlo Cesana and Maria Dimitriou and Alex S. F. Doney and Angela D{\"o}ring and Paul Elliott and Stephen E. Epstein and Gudmundur Ingi Eyjolfsson and Bruna Gigante and Mark O Goodarzi and Harald Grallert and Martha L. Gravito and Christopher James Groves and Göran Hallmans and A Hartikainen and Caroline Hayward and D. G. Perez Hernandez and Andrew A Hicks and Hilma H{\'o}lm and Yi-Jen Hung and Thomas Illig and Michelle R. Jones and Pontiano Kaleebu and John J. P. Kastelein and Kay-tee Khaw and Eric Kim and Norman Klopp and Pirjo Komulainen and Meena Kumari and Claudia Langenberg and Terho Lehtim{\"a}ki and Shih-Yi Lin and Jaana Lindstr{\"o}m and Ruth J F Loos and François Mach and Wendy L. Mcardle and Christa Meisinger and Braxton D. Mitchell and Gabrielle Mueller and Ramaiah Nagaraja and Narisu Narisu and Tuomo V.M. Nieminen and Rebecca N. Nsubuga and Isleifur Olafsson and Ken K Ong and Aarno Palotie and Theodore Papamarkou and Cristina Pomilla and Anneli Pouta and D. J. Rader and Muredach P. Reilly and Paul M. Ridker and Fernando Rivadeneira and Igor Rudan and Aimo O Ruokonen and Nilesh J. Samani and Hubert Scharnagl and Janet Seeley and Kaisa Silander and Alena Stan{\vc}{\'a}kov{\'a} and Kathleen E Stirrups and Amy J. Swift and Laurence Tiret and Andr{\'e} G. Uitterlinden and L. Joost van Pelt and Sailaja L. Vedantam and Nicholas W. J. Wainwright and Cisca Wijmenga and Sarah H Wild and Gonneke H. M. Willemsen and Tom Wilsgaard and James F Wilson and Elizabeth H. Young and Jing Hua Zhao and LindaS. Adair and Dominique Arveiler and Themistocles L. Assimes and Stefania Bandinelli and Franklyn I. Bennett and Murielle Bochud and B O Boehm and Dorret I. Boomsma and Ingrid B. Borecki and Stefan R. Bornstein and Pascal Bovet and Michel Burnier and Harry Campbell and Aravinda Chakravarti and John Campbell Chambers and Yii-Der I. Chen and Francis S. Collins and Richard S. Cooper and John Danesh and George Vassilios Dedoussis and Ulf de Faire and Alan B. Feranil and Jean Ferri{\`e}res and Luigi Ferrucci and Nelson B. Freimer and Christian Gieger and Leif Groop and Vilmundur Gudnason and Ulf Gyllensten and Anders Hamsten and T. B. Harris and Aroon Hingorani and Joel Hirschhorn and Albert Hofman and G. K. Hovingh and Chao A. Hsiung and Steve E Humphries and Steven C. Hunt and Kristian Hveem and Carlos Iribarren and Marjo-Riitta J{\"a}rvelin and Antti Jula and Mika K{\"a}h{\"o}nen and Jaakko Kaprio and Antero Kes{\"a}niemi and Mika Kivimaki and Jaspal Singh Kooner and Peter J Koudstaal and Ronald M. Krauss and Diana Kuh and Johanna Kuusisto and Kirsten Ohm Kyvik and Markku Laakso and Timo A Lakka and Lars Lind and Cecilia M. Lindgren and Nicholas G. Martin and Winfried Maerz and Mark I. McCarthy and Colin A. Mckenzie and Pierre Meneton and Andres Metspalu and Leena Moilanen and Andrew D. Morris and Patricia B. Munroe and Inger Nj{\o}lstad and Carsten B{\o}cker Pedersen and Chris Power and Peter P. Pramstaller and Jackie F. Price and Bruce M. Psaty and Thomas Quertermous and Rainer Rauramaa and Danish Saleheen and Veikko V Salomaa and Dharambir K Sanghera and Jouko Saramies and Peter E. H. Schwarz and Wayne H-H Sheu and Alan R. Shuldiner and Agneta Siegbahn and Tim D. Spector and K{\'a}ri Stef{\'a}nsson and David P Strachan and Bamidele O. Tayo and Elena Tremoli and Jaakko Tuomilehto and Matti Uusitupa and Cornelia M van Duijn and Peter Vollenweider and Lars Wallentin and Nicholas J Wareham and John B. Whitfield and Bruce H. R. Wolffenbuttel and Jos{\'e} M. Ordov{\'a}s and Eric Boerwinkle and Colin N A Palmer and Unnur Thorsteinsdottir and Daniel I. Chasman and Jerome I. Rotter and Paul W Franks and Samuli Ripatti and L Adrienne Cupples and Manjinder S. Sandhu and Stephen S. Rich and Michael Boehnke and Panos Deloukas and Sekar Kathiresan and Karen L. Mohlke and Erik Ingelsson and Gonçalo R. Abecasis},
  booktitle={Nature Genetics},
Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 × 10−8, including 62 loci not previously associated with lipid levels in… CONTINUE READING


Publications citing this paper.

1,068 Citations

Citations per Year
Semantic Scholar estimates that this publication has 1,068 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.

Evaluation of the metabochip genotyping array in African Americans and implications for fine mapping of GWAS-identified loci: the PAGE study

  • S Buyske
  • PLoS ONE
  • 2012

Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations

  • A Demirkan
  • PLoS Genet
  • 2012

Genetic variants in novel pathways influence blood pressure and cardiovascular disease

  • GB Ehret
  • risk. Nature
  • 2011

Similar Papers

Loading similar papers…