Discovery and Isolation of Anandamide and Other Endocannabinoids

  title={Discovery and Isolation of Anandamide and Other Endocannabinoids},
  author={L. Hanu{\vs}},
  journal={Chemistry \& Biodiversity},
  • L. Hanuš
  • Published 2007
  • Chemistry, Medicine
  • Chemistry & Biodiversity
Terpenes/Terpenoids in Cannabis: Are They Important?
The main terpenes/terpenoids and their abundance in the samples were evaluated and will be helpful in the next evaluation of these compound in mixture with cannabinoids and their importance in medical treatment. Expand
Substance Use Disorders
The present chapter aims at providing a comprehensive overview on birth defects, foetal malformations, teratogenic risk and perinatal complications related to the consumption of cannabinoids, opioids and psychostimulant drugs during pregnancy. Expand
Synthesis of novel 2-(1-adamantanylcarboxamido)thiophene derivatives. Selective cannabinoid type 2 (CB2) receptor agonists as potential agents for the treatment of skin inflammatory disease.
The full agonist 8g, showing the best balance between receptor affinity and selectivity, was tested in vitro in an experimental model of allergic contact dermatitis and proved to be able to block the release of MCP-2 in HaCaT cells at 10 μM concentration. Expand
Determination of the Endocannabinoids Anandamide and 2-Arachidonoyl Glycerol with Gas Chromatography-Mass Spectrometry: Analytical and Preanalytical Challenges and Pitfalls
Background: The endocannabinoids anandamide (N-arachidonoyl ethanolamide [AEA]) and 2-arachidonoyl glycerol (2-AG) are involved in the regulation of neuronal, immune, metabolic, vascular, andExpand
Cannabis through the looking glass: chemo- and enantio-selective separation of phytocannabinoids by enantioselective ultra high performance supercritical fluid chromatography.
An enantioselective UHPSFC method is developed to determine the enantiomeric excess of (-)-Δ9-THC in medicinal marijuana (Bedrocan®) and the ee was high, but the concentration of the (+)-enantiomer was not negligible, and it is worth a systematic evaluation of bioactivity. Expand
Biosynthesis and Fate of Endocannabinoids.
The primary biosynthetic and metabolic pathways for the two well-established endocannabinoids, anandamide and 2-arachidonoylglycerol are described. Expand
Plasma anandamide and related n-acylethanolamide levels are not elevated in pregnancies complicated by hyperemesis gravidarum
  • A. Gebeh, J. Willets, T. Marczylo, J. Konje
  • Medicine
  • The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2014
The results would suggest that either the circulating endocannabinoids quantified may not be key modulating factors in HG or that the expected endoc cannabinoidoid system response to the stress induced by nausea and vomiting of early pregnancy remain unchanged in women with HG. Expand
PNS1300341 451..459
Following on from the discovery of cannabinoid receptors, of their endogenous agonists (endocannabinoids) and of the biosynthetic and metabolic enzymes of the endocannabinoids, significant progressExpand
PUFA-derived endocannabinoids: an overview
  • M. Cascio
  • Medicine, Chemistry
  • Proceedings of the Nutrition Society
  • 2013
An overview of what is currently known about the mechanisms for the biosynthesis and inactivation of endocannabinoids, together with a brief analysis of the involvement of the endoc cannabinoidoids in both food intake and obesity is provided. Expand


  • R. Rosenfeld
  • Medicine
  • Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • 2009
I am writing with a simple plea to balance the voluminous articles about treatment in your journal with a modicum of information about nature and caring effects to rekindle the perception of physicians as healers, not only treaters, who relish the gifts of nature, and foster the humanistic aspect of medicine that has thrived for millennia. Expand
An archaeological and historical account of cannabis in China
Although Cannabis is generally believed to be of Asiatic origin, within this vast geographical area, there is no general agreement as to where the domestication really came about. Alphonse deExpand
ISI Web of Knowledge, Web of Science
  • ISI Web of Knowledge, Web of Science
  • 2007
  • 2007
A FAAH-regulated class of N-acyl taurines that activates TRP ion channels.
The dramatic elevation in endogenous levels of NATs following acute or chronic inactivation of FAAH, in conjunction with the pharmacological effects of these lipids on TRP channels, suggests the existence of a second major lipid signaling system regulated by FAAH in vivo. Expand
Biol. Reprod
  • Biol. Reprod
  • 2006
Br. J. Pharmacol
  • Br. J. Pharmacol
  • 2006
Lett. Drug Des. Discov
  • Lett. Drug Des. Discov
  • 2006
N-arachidonoyl l-serine, an endocannabinoid-like brain constituent with vasodilatory properties
  • G. Milman, Y. Maor, +8 authors R. Mechoulam
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2006
ARA-S may represent an endogenous agonist for this receptor and produces endothelium-dependent vasodilation of rat isolated mesenteric arteries and abdominal aorta and stimulates phosphorylation of p44/42 mitogen-activated protein (MAP) kinase and protein kinase B/Akt in cultured endothelial cells. Expand