Discovery and Isolation of Anandamide and Other Endocannabinoids

  title={Discovery and Isolation of Anandamide and Other Endocannabinoids},
  author={Lum{\'i}r Ondřej Hanu{\vs}},
  journal={Chemistry \& Biodiversity},
  • L. Hanuš
  • Published 1 August 2007
  • Biology
  • Chemistry & Biodiversity

Cannabidiol in clinical and preclinical anxiety research. A systematic review into concentration–effect relations using the IB-de-risk tool

A straightforward dosing recommendation was not possible, given variable concentration–effect relations across species, and no consistent linear effect of CBD on anxiety reduction, which raises questions about the broad use as a drug for anxiety.


Using nanofiltration membranes for the recovery of phosphorous with a second type of technology for theovery of nitrogen is suggest to be a viable process.

“The Two Sides of the Same Coin”—Medical Cannabis, Cannabinoids and Immunity: Pros and Cons Explained

It is proposed that much is still unknown about adverse reactions to cannabis use, and its integration with medical treatment should be conducted cautiously with consideration of the individual patient, effector cells, microenvironment, and the immune system.

Cannabigerol: a bibliometric overview and review of research on an important phytocannabinoid

In-depth analysis of the published literature revealed that clinical trials establishing the efficacy, safety and side-effects of CBG therapy in specific disease conditions are limited, as well as industry-friendly quality control procedures for CBG-enriched cannabis extracts.

Terpenes/Terpenoids in Cannabis: Are They Important?

The main terpenes/terpenoids and their abundance in the samples were evaluated and will be helpful in the next evaluation of these compound in mixture with cannabinoids and their importance in medical treatment.

Substance Use Disorders

The present chapter aims at providing a comprehensive overview on birth defects, foetal malformations, teratogenic risk and perinatal complications related to the consumption of cannabinoids, opioids and psychostimulant drugs during pregnancy.

Determination of the Endocannabinoids Anandamide and 2-Arachidonoyl Glycerol with Gas Chromatography-Mass Spectrometry: Analytical and Preanalytical Challenges and Pitfalls

Overall, limited in vitro and/or in vivo/ex vivo chemical stability of endocannabinoids has to be taken into account.

Cannabis through the looking glass: chemo- and enantio-selective separation of phytocannabinoids by enantioselective ultra high performance supercritical fluid chromatography.

An enantioselective UHPSFC method is developed to determine the enantiomeric excess of (-)-Δ9-THC in medicinal marijuana (Bedrocan®) and the ee was high, but the concentration of the (+)-enantiomer was not negligible, and it is worth a systematic evaluation of bioactivity.

Biosynthesis and Fate of Endocannabinoids.

The primary biosynthetic and metabolic pathways for the two well-established endocannabinoids, anandamide and 2-arachidonoylglycerol are described.



Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish

strongly solvated than triple ions,lb-5 the difference being greater for cations of smaller radii, leading to a trend to smaller K with decreasing cationic radii. Both effects, in opposite