Discovery and Development of Small Molecule Allosteric Modulators of Glycoprotein Hormone Receptors

@inproceedings{Nataraja2015DiscoveryAD,
  title={Discovery and Development of Small Molecule Allosteric Modulators of Glycoprotein Hormone Receptors},
  author={Selvaraj G. Nataraja and Henry Yu and Stephen Sunderland Palmer},
  booktitle={Front. Endocrinol.},
  year={2015}
}
Glycoprotein hormones, follicle-stimulating hormone (FSH), luteinizing hormone (LH), and thyroid-stimulating hormone (TSH) are heterodimeric proteins with a common α-subunit and hormone-specific β-subunit. These hormones are dominant regulators of reproduction and metabolic processes. Receptors for the glycoprotein hormones belong to the family of G protein-coupled receptors. FSH receptor (FSHR) and LH receptor are primarily expressed in somatic cells in ovary and testis to promote egg and… CONTINUE READING
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