Discovery That Theonellasterol a Marine Sponge Sterol Is a Highly Selective FXR Antagonist That Protects against Liver Injury in Cholestasis

@inproceedings{Renga2012DiscoveryTT,
  title={Discovery That Theonellasterol a Marine Sponge Sterol Is a Highly Selective FXR Antagonist That Protects against Liver Injury in Cholestasis},
  author={Barbara Renga and Andrea Mencarelli and Claudio D'Amore and Sabrina Cipriani and Maria Valeria D'auria and Valentina Sepe and Maria G Chini and Maria Chiara Monti and Giuseppe Bifulco and Angela Zampella and Stefano Fiorucci},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND The farnesoid-x-receptor (FXR) is a bile acid sensor expressed in the liver and gastrointestinal tract. Despite FXR ligands are under investigation for treatment of cholestasis, a biochemical condition occurring in a number of liver diseases for which available therapies are poorly effective, mice harboring a disrupted FXR are protected against liver injury caused by bile acid overload in rodent models of cholestasis. Theonellasterol is a 4-methylene-24-ethylsteroid isolated from the… CONTINUE READING

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Highly Influential
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