Discovery, SAR, synthesis, pharmacokinetic and biochemical characterization of A-192411: a novel fungicidal lipopeptide-(I).

Abstract

The echinocandin class of cyclic lipopeptides has been simplified to discover potent antifungal compounds. Namely A-192411 shows good in vitro activity against common pathogenic yeasts and has an acceptable safety window in vivo. Discovery, limited SAR, synthesis, biochemical and pharmaco-dynamic profiles of A-192411 are presented.

Cite this paper

@article{Wang2003DiscoverySS, title={Discovery, SAR, synthesis, pharmacokinetic and biochemical characterization of A-192411: a novel fungicidal lipopeptide-(I).}, author={Weibo Wang and Qun Li and Lisa A. Hasvold and Beth Steiner and Daniel A Dickman and Hong Ding and Akyio Clairborne and Hui-Ju Chen and David J. Frost and Robert C Goldman and Kennan C. Marsh and Yu-hua Hui and Brian G. Cox and Angela M Nilius and Darlene J Balli and Paul Lartey and Jacob J. Plattner and Youssef Bennani}, journal={Bioorganic & medicinal chemistry letters}, year={2003}, volume={13 3}, pages={489-93} }