Discovery, purification and characterization of the angiotensin converting enzyme inhibitor, L-681,176, produced by Streptomyces sp. MA 5143a.

@article{Huang1984DiscoveryPA,
  title={Discovery, purification and characterization of the angiotensin converting enzyme inhibitor, L-681,176, produced by Streptomyces sp. MA 5143a.},
  author={L. H. Huang and G L Rowin and Jennifer Dunn and Richard Brook Sykes and R Dobna and B A Mayles and D. M. Gross and Richard W. Burg},
  journal={The Journal of antibiotics},
  year={1984},
  volume={37 5},
  pages={
          462-5
        }
}
L-681,176, an inhibitor of angiotensin converting enzyme was found in the culture filtrate of Streptomyces sp. MA 5143. The I50 of the crystalline inhibitor is about 1.3 micrograms/ml and the inhibition is reversed by zinc sulfate. In rats, L-681,176 exhibits a dose-related inhibition of the pressor response to angiotensin I with an ID50 of 142 mg/kg when administered intravenously. The structure of L-681,176 is similar to that of marasmine but lacking one carboxyl group. The maximum yield of L… 
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