Discovery, design and synthesis of a selective S1P(3) receptor allosteric agonist.

@article{Guerrero2013DiscoveryDA,
  title={Discovery, design and synthesis of a selective S1P(3) receptor allosteric agonist.},
  author={M. Guerrero and Ramulu Poddutoori and M. Urbano and Xuemei Peng and T. Spicer and P. Chase and P. Hodder and M. Schaeffer and S. Brown and H. Rosen and E. Roberts},
  journal={Bioorganic \& medicinal chemistry letters},
  year={2013},
  volume={23 23},
  pages={
          6346-9
        }
}
Potent and selective S1P3 receptor (S1P3-R) agonists may represent important proof-of-principle tools used to clarify the receptor biological function and assess the therapeutic potential of the S1P3-R in cardiovascular, inflammatory and pulmonary diseases. N,N-Dicyclohexyl-5-propylisoxazole-3-carboxamide was identified by a high-throughput screening of MLSMR library as a promising S1P3-R agonist. Rational chemical modifications of the hit allowed the identification of N,N-dicyclohexyl-5… Expand
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