Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4.

@article{Niswender2008DiscoveryCA,
  title={Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4.},
  author={Colleen M Niswender and Kari A. Johnson and C David Weaver and Carrie K Jones and Zixiu Xiang and Qingwei Luo and Alice Lambert Rodriguez and Joy Marlo and Tomas de Paulis and Analisa D. Thompson and Emily L. Days and Tasha Nalywajko and Cheryl A Austin and Michael Baxter Williams and Jennifer Edl Ayala and Richard D. Williams and Craig W Linsdley and Peter Jeffrey Conn},
  journal={Molecular pharmacology},
  year={2008},
  volume={74 5},
  pages={
          1345-58
        }
}
Parkinson's disease (PD) is caused by the death of dopamine neurons in the basal ganglia and results in motor symptoms such as tremor and bradykinesia. Activation of metabotropic glutamate receptor 4 (mGluR4) has been shown to modulate neurotransmission in the basal ganglia and results in antiparkinsonian effects in rodent PD models. N-Phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxamide (PHCCC) is a positive allosteric modulator (PAM) of mGluR4 that has been used to further validate the… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 67 CITATIONS, ESTIMATED 39% COVERAGE

Metabotropic Receptors for Glutamate and GABA

VIEW 8 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Re-exploration of the PHCCC Scaffold: Discovery of Improved Positive Allosteric Modulators of mGluR4.

  • ACS chemical neuroscience
  • 2010
VIEW 8 EXCERPTS
CITES BACKGROUND, RESULTS & METHODS
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2007
2018

CITATION STATISTICS

  • 14 Highly Influenced Citations

References

Publications referenced by this paper.
SHOWING 1-10 OF 33 REFERENCES

Group III metabotropic glutamate receptor-mediated modulation of the striatopallidal synapse.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2003
VIEW 18 EXCERPTS
HIGHLY INFLUENTIAL

Targeting group III metabotropic glutamate receptors produces complex behavioral effects in rodent models of Parkinson's disease.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2007
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

Allosteric modulation of group III metabotropic glutamate receptor 4: a potential approach to Parkinson's disease treatment.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2003
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL

Similar Papers

Loading similar papers…