Discovery, biosynthesis, and mechanism of action of the zaragozic acids: potent inhibitors of squalene synthase.

@article{Bergstrom1995DiscoveryBA,
  title={Discovery, biosynthesis, and mechanism of action of the zaragozic acids: potent inhibitors of squalene synthase.},
  author={James D. Bergstrom and Christiane Dufresne and Gerald F Bills and Mary Nallin-Omstead and Kevin Byrne},
  journal={Annual review of microbiology},
  year={1995},
  volume={49},
  pages={607-39}
}
The zaragozic acids (ZAs), a family of fungal metabolites containing a novel 4,6,7-trihydroxy-2,8-dioxobicyclo[3.2.1]octane-3,4,5-tricarboxylic acid core, were discovered independently by two separate groups screening natural product sources to discover inhibitors of squalene synthase. This family of compounds all contain the same core but differ in their 1-alkyl and their 6-acyl side chains. Production of the ZAs is distributed over an extensive taxonomic range of Ascomycotina or their… CONTINUE READING
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