Discovery, biochemistry and biology of lovastatin.

@article{Alberts1988DiscoveryBA,
  title={Discovery, biochemistry and biology of lovastatin.},
  author={Alfred Alberts},
  journal={The American journal of cardiology},
  year={1988},
  volume={62 15},
  pages={10J-15J}
}
Cholesterol is a 27-carbon steroid that is an essential component of the cell membrane, the immediate precursor of steroid hormones, the substrate for the formation of bile acids, and is required for the assembly of very low density lipoprotein in the liver. Because as much as two-thirds of total body cholesterol in patients is of endogenous origin, an effective means to control cholesterogenesis may occur by inhibition of its biosynthesis. Cholesterol is biosynthesized in a series of more than… CONTINUE READING
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