Discovering pluripotency: 30 years of mouse embryonic stem cells

  title={Discovering pluripotency: 30 years of mouse embryonic stem cells},
  author={Martin Evans},
  journal={Nature Reviews Molecular Cell Biology},
Embryonic stem (ES) cells are pluripotent cells isolated from an early embryo and grown as a cell line in tissue culture. Their discovery came from the conjunction of studies in human pathology, mouse genetics, early mouse embryo development, cell surface immunology and tissue culture. ES cells provided a crucial tool for manipulating mouse embryos to study mouse genetics, development and physiology. They have not only revolutionized experimental mammalian genetics but, with the advent of… CONTINUE READING