Discovering oxysterols in plasma: a window on the metabolome.

  title={Discovering oxysterols in plasma: a window on the metabolome.},
  author={William J Griffiths and Martin P. Hornshaw and Gary Woffendin and Sharon F Baker and Andrew Lockhart and Sibylle Heidelberger and Magnus Gustafsson and Jan Sj{\"o}vall and Yuqin Wang},
  journal={Journal of proteome research},
  volume={7 8},
While the proteome defines the expressed gene products, the metabolome results from reactions controlled by such gene products. Plasma represents an accessible "window" to the metabolome both in regard of availability and content. The wide range of the plasma metabolome, in terms of molecular diversity and abundance, makes its comprehensive analysis challenging. Here we demonstrate an analytical method designed to target one region of the metabolome, that is, oxysterols. Since the discovery of… CONTINUE READING


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