Discovering neutralizing antibodies targeting the stem epitope of H1N1 influenza hemagglutinin with synthetic phage-displayed antibody libraries

@inproceedings{Tung2015DiscoveringNA,
  title={Discovering neutralizing antibodies targeting the stem epitope of H1N1 influenza hemagglutinin with synthetic phage-displayed antibody libraries},
  author={Chao-Ping Tung and Ing-Chien Chen and Chung-Ming Yu and Hung-Pin Peng and Jhih-Wei Jian and Shiou-Hwa Ma and Yu-Ching Lee and Jia-Tsrong Jan and An-Suei Yang},
  booktitle={Scientific reports},
  year={2015}
}
Broadly neutralizing antibodies developed from the IGHV1-69 germline gene are known to bind to the stem region of hemagglutinin in diverse influenza viruses but the sequence determinants for the antigen recognition, including neutralization potency and binding affinity, are not clearly understood. Such understanding could inform designs of synthetic antibody libraries targeting the stem epitope on hemagglutinin, leading to artificially designed antibodies that are functionally advantageous over… CONTINUE READING
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