Discovering high-resolution patterns of differential DNA methylation that correlate with gene expression changes

@inproceedings{VanderKraats2013DiscoveringHP,
  title={Discovering high-resolution patterns of differential DNA methylation that correlate with gene expression changes},
  author={Nathan D. VanderKraats and Jeffrey F. Hiken and Keith F. Decker and John Richard Edwards},
  booktitle={Nucleic acids research},
  year={2013}
}
Methylation of the CpG-rich region (CpG island) overlapping a gene's promoter is a generally accepted mechanism for silencing expression. While recent technological advances have enabled measurement of DNA methylation and expression changes genome-wide, only modest correlations between differential methylation at gene promoters and expression have been found. We hypothesize that stronger associations are not observed because existing analysis methods oversimplify their representation of the… CONTINUE READING
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