Discovering functional linkages and uncharacterized cellular pathways using phylogenetic profile comparisons: a comprehensive assessment

@article{Jothi2007DiscoveringFL,
  title={Discovering functional linkages and uncharacterized cellular pathways using phylogenetic profile comparisons: a comprehensive assessment},
  author={Raja Jothi and Teresa M. Przytycka and L. Aravind},
  journal={BMC Bioinformatics},
  year={2007},
  volume={8},
  pages={173 - 173}
}
A widely-used approach for discovering functional and physical interactions among proteins involves phylogenetic profile comparisons (PPCs). Here, proteins with similar profiles are inferred to be functionally related under the assumption that proteins involved in the same metabolic pathway or cellular system are likely to have been co-inherited during evolution. Our experimentation with E. coli and yeast proteins with 16 different carefully composed reference sets of genomes revealed that the… CONTINUE READING
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