Discovering DNA: Friedrich Miescher and the early years of nucleic acid research

@article{Dahm2007DiscoveringDF,
  title={Discovering DNA: Friedrich Miescher and the early years of nucleic acid research},
  author={Ralf Dahm},
  journal={Human Genetics},
  year={2007},
  volume={122},
  pages={565-581}
}
  • R. Dahm
  • Published 2007
  • Biology
  • Human Genetics
In the winter of 1868/9 the young Swiss doctor Friedrich Miescher, working in the laboratory of Felix Hoppe-Seyler at the University of Tübingen, performed experiments on the chemical composition of leukocytes that lead to the discovery of DNA. [] Key Result Its properties during the isolation procedure and its resistance to protease digestion indicated that the novel substance was not a protein or lipid.
Historic nucleic acids isolated by Friedrich Miescher contain RNA besides DNA
Abstract One hundred fifty years ago, Friedrich Miescher discovered DNA when he isolated “Nuclein”—as he named it—from nuclei of human pus cells. Miescher recognized his isolate as a new type of
Serendipity and the Discovery of DNA
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The First Discovery of DNA Few remember the man who discovered the "molecule of life" three-quarters of a century before Watson and Crick revealed its structure
On February 26, 1869, in the old university town of T?bingen in southwest Germany, the young Swiss doctor Friedrich Miescher, who had settled there only a few months earlier, completed a letter to
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Before Watson and Crick in 1953 Came Friedrich Miescher in 1869
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It is highlighted that Miescher could just as correctly be portrayed as the person who understood the chemical nature of chromatin (before the term existed), and the first to suggest how stereochemistry might serve as the basis for the transmission of hereditary variation.
From discovering to understanding
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Friedrich Miescher, the Swiss scientist who discovered DNA in 1869, developed surprisingly insightful theories to explain its function and how biological molecules could encode information, which came tantalizingly close to current understanding.
Discovery of DNA Structure and Function: Watson and Crick
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Without the scientific foundation provided by these pioneers, Watson and Crick may never have reached their groundbreaking conclusion of 1953: that the DNA molecule exists in the form of a three-dimensional double helix.
The birth and development of the DNA theory of inheritance: sixty years since the discovery of the structure of DNA
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The development of the DNA theory of inheritance culminated in the publication of the molecular structure of DNA 60 years ago, and the discovery of the double helix in 1953 is described.
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