Discordant temporal evolution of Pfcrt and Pfmdr1 genotypes and Plasmodium falciparum in vitro drug susceptibility to 4-aminoquinolines after drug policy change in French Guiana.

@article{Legrand2012DiscordantTE,
  title={Discordant temporal evolution of Pfcrt and Pfmdr1 genotypes and Plasmodium falciparum in vitro drug susceptibility to 4-aminoquinolines after drug policy change in French Guiana.},
  author={Eric Legrand and Jos{\'e}phine Yrinesi and Marie-Th{\'e}r{\`e}se Ekala and Julie P{\'e}neau and B{\'e}atrice Volney and Franck Berger and Christiane Bouchier and St{\'e}phane Bertani and Lise Musset and Jean-Baptiste Meynard and Odile Mercereau-Puijalon},
  journal={Antimicrobial agents and chemotherapy},
  year={2012},
  volume={56 3},
  pages={1382-9}
}
Analysis of the evolution of drug target genes under changing drug policy is needed to assist monitoring of Plasmodium falciparum drug resistance in the field. Here we genotype Pfcrt and Pfdmr1 of 700 isolates collected in French Guiana from 2000 (5 years after withdrawal of chloroquine) to 2008, i.e., the period when the artemether-lumefantrine combination… CONTINUE READING