Discordant responses on starting highly active antiretroviral therapy: suboptimal CD4 increases despite early viral suppression in the UK Collaborative HIV Cohort (UK CHIC) Study.

@article{Gilson2010DiscordantRO,
  title={Discordant responses on starting highly active antiretroviral therapy: suboptimal CD4 increases despite early viral suppression in the UK Collaborative HIV Cohort (UK CHIC) Study.},
  author={Richard John Cary Gilson and S Man and Andrew J Copas and Alex Rider and Sarah Forsyth and Tamsey Hill and Loveleen K Bansi and Kristin Porter and B Gazzard and Carl Orkin and Deenan Pillay and Achim Schwenk and M Johnson and P Easterbook and Janice Walsh and M Fisher and Clifford S Leen and Jennifer J. Anderson and Caroline Sabin},
  journal={HIV medicine},
  year={2010},
  volume={11 2},
  pages={152-60}
}
OBJECTIVES Patients starting highly active antiretroviral therapy (HAART) may have a suboptimal CD4 increase despite rapid virological suppression. The frequency and the significance for patient care of this discordant response are uncertain. This study was designed to determine the incidence of a discordant response at two time-points, soon after 6 months and at 12 months, and to determine the relationship with clinical outcomes. METHODS Data obtained in the UK Collaborative HIV Cohort Study… CONTINUE READING
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