Discordant responses on starting highly active antiretroviral therapy: suboptimal CD4 increases despite early viral suppression in the UK Collaborative HIV Cohort (UK CHIC) Study.

@article{Gilson2010DiscordantRO,
  title={Discordant responses on starting highly active antiretroviral therapy: suboptimal CD4 increases despite early viral suppression in the UK Collaborative HIV Cohort (UK CHIC) Study.},
  author={Richard John Cary Gilson and S Man and Andrew J Copas and Ann Rider and Sharon Forsyth and Teresa A. Garrett Hill and Loveleen K Bansi and Kholoud Porter and Brian Gazzard and Chloe M. Orkin and Deenan Pillay and Achim Schwenk and Margaret A T Johnson and P Easterbook and John Walsh and Martin Fisher and Clifford S Leen and Jane K Anderson and Caroline Sabin},
  journal={HIV medicine},
  year={2010},
  volume={11 2},
  pages={152-60}
}
OBJECTIVES Patients starting highly active antiretroviral therapy (HAART) may have a suboptimal CD4 increase despite rapid virological suppression. The frequency and the significance for patient care of this discordant response are uncertain. This study was designed to determine the incidence of a discordant response at two time-points, soon after 6 months and at 12 months, and to determine the relationship with clinical outcomes. METHODS Data obtained in the UK Collaborative HIV Cohort Study… CONTINUE READING