Discordant changes in cortical TrkC mRNA and protein during the human lifespan.

@article{Beltaifa2005DiscordantCI,
  title={Discordant changes in cortical TrkC mRNA and protein during the human lifespan.},
  author={Senda Beltaifa and Maree J. Webster and Davinna L Ligons and Robert J Fatula and Mary M. Herman and Joel Edward Kleinman and Cynthia Shannon Weickert},
  journal={The European journal of neuroscience},
  year={2005},
  volume={21 9},
  pages={2433-44}
}
Neurotrophin-3 (NT-3) exerts its trophic effects in brain via tyrosine kinase receptor C (trkC) signaling. TrkC splice variants produce receptors with (full-length) and without (truncated) a tyrosine kinase domain. The relative abundance of trkC isoforms and the anatomical localization of trkC in the human prefrontal cortex (PFC) in relationship to development and maturation are currently unknown. We have examined the temporo-spatial expression of trkC protein and mRNA during the development of… CONTINUE READING

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