Discordance of UPR signaling by ATF6 and Ire1p-XBP1 with levels of target transcripts.

@article{Shang2004DiscordanceOU,
  title={Discordance of UPR signaling by ATF6 and Ire1p-XBP1 with levels of target transcripts.},
  author={Jie Shang and Mark A. Lehrman},
  journal={Biochemical and biophysical research communications},
  year={2004},
  volume={317 2},
  pages={390-6}
}
Accumulation of misfolded proteins within the lumen of the mammalian endoplasmic reticulum (ER) activates the unfolded protein response (UPR). ATF6 and Ire1p are ER-associated proteins that control UPR-specific transcription systems in mammals; UPR signaling involves cleavage of ATF6 and splicing of XBP1 mRNA initiated by Ire1p. We tested the hypothesis that activation of ATF6 and/or Ire1p determines the levels of mRNAs derived from target genes encoding GRP78/BiP and EDEM. By subjecting dermal… CONTINUE READING

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