Discordance in the effects of interleukin-1 on rat granulosa cell differentiation induced by follicle-stimulating hormone or activators of adenylate cyclase.

  title={Discordance in the effects of interleukin-1 on rat granulosa cell differentiation induced by follicle-stimulating hormone or activators of adenylate cyclase.},
  author={Paul E. Gottschall and Goro Katsuura and R R Dahl and Stephanie Hoffmann and Akira Arimura},
  journal={Biology of reproduction},
  volume={39 5},
Recombinant human interleukin-1 (IL-1) inhibits the follicle-stimulating hormone (FSH)-induced development of luteinizing hormone (LH) receptors and suppresses progesterone secretion in cultured rat granulosa cells. Since activation of adenylate cyclase by FSH is considered to be the primary second messenger system responsible for differentiation of granulosa cells, we examined whether IL-1 could alter the FSH, cholera toxin, or forskolin-induced accumulation of cyclic adenosine 3', 5… 

Rabbit ovarian production of interleukin-6 and its potential effects on gonadotropin-induced progesterone secretion in granulosa and theca cells.

The results suggest that gonadotropins, by inhibiting IL-6 production, could control, in the authors' model, IL- 6 modulation of gonadotropic action on steroidogenesis.

Lymphokines, including interleukin-2, alter gonadotropin-stimulated progesterone production and proliferation of human granulosa-luteal cells in vitro.

It is concluded that human recombinant IL-2 significantly inhibits progesterone production stimulated by hCG in human granulosa-luteal cells and had a marked inhibitory effect on forskolin-induced progestersone release.

Effects of Bacterial Endotoxin (Lipopolysaccharide) on FSH-Induced Granulosa Cell Activities

The preliminary results have shown that bacterial endotoxin (lipopolysaccharide, LPS) exerted inhibitory effects on FSH-induced formation of LH receptors in rat GCs, suggesting the possibility that LPS may act either directly on GCs or may act indirectly by inducing the production of a secondary factor that influences GC function.

Cytokine-mediated regulation of ovarian function: interleukin-1 inhibits gonadotropin-induced androgen biosynthesis.

Findings indicate that relatively low concentrations of IL-1, possibly originating from somatic ovarian cells or resident ovarian macrophages, are capable of exerting an inhibitory effect upon gonadotropin-supported androgen production.

Regulation of rat granulosa cell plasminogen activator system: influence of interleukin-1 beta and ovarian follicular development.

During ovarian folliculogenesis, IL-1 beta may modulate the progression of granulosa cells from a proliferative to a differentiated state and may play a control role in determining the fate of the follicle (i.e., ovulation vs. atresia).

Interleukin-2 affects steroidogenesis and numbers of bovine ovarian granulosa cells but not thecal cellsin vitro

It appears that granulosa cells are more sensitive to IL-2 than are thecal cells, as they were studied independently under serum-free conditions and media enriched with 10% fetal calf serum.

Divergent effects of interleukin-1 beta on steroidogenesis and matrix metalloproteinase inhibitor expression and activity in cultured rat granulosa cells.

It is concluded from the current study that IL-1 beta is a mediator of MMPI expression as well as granulosa cell steroidogenesis, and that this cytokine has divergent actions in the presence and absence of LH.