Discordance in the effects of interleukin-1 on rat granulosa cell differentiation induced by follicle-stimulating hormone or activators of adenylate cyclase.

@article{Gottschall1988DiscordanceIT,
  title={Discordance in the effects of interleukin-1 on rat granulosa cell differentiation induced by follicle-stimulating hormone or activators of adenylate cyclase.},
  author={Paul E. Gottschall and Goro Katsuura and R R Dahl and Stephanie Hoffmann and Akira Arimura},
  journal={Biology of reproduction},
  year={1988},
  volume={39 5},
  pages={
          1074-85
        }
}
Recombinant human interleukin-1 (IL-1) inhibits the follicle-stimulating hormone (FSH)-induced development of luteinizing hormone (LH) receptors and suppresses progesterone secretion in cultured rat granulosa cells. Since activation of adenylate cyclase by FSH is considered to be the primary second messenger system responsible for differentiation of granulosa cells, we examined whether IL-1 could alter the FSH, cholera toxin, or forskolin-induced accumulation of cyclic adenosine 3', 5… 

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