Discordance in HER2 gene amplification in circulating and disseminated tumor cells in patients with operable breast cancer

@inproceedings{Krishnamurthy2013DiscordanceIH,
  title={Discordance in HER2 gene amplification in circulating and disseminated tumor cells in patients with operable breast cancer},
  author={Savitri Krishnamurthy and Farideh Z. Bischoff and Julie Ann Mayer and Karina L. Wong and Tam Pham and Henry Mark Kuerer and Ashutosh K. Lodhi and Anirban Bhattacharyya and Carolyn S. Hall and Anthony J. Lucci},
  booktitle={Cancer medicine},
  year={2013}
}
Human epidermal growth factor receptor 2 (HER2) gene amplification in circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) might be useful for modifying Herceptin therapy in breast cancer. In the process of investigating the utility of a microfluidic platform for detecting HER2 gene amplification in these cells, we observed novel results on discordance of HER2 status. Peripheral blood (8.5 mL) and bone marrow (BM) (7.5-10 mL) were collected prospectively from patients with… CONTINUE READING
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