Discordance between the anti-Xa activity and the antithrombotic activity in an ultra-low molecular weight heparin fraction.

@article{Ockelford1982DiscordanceBT,
  title={Discordance between the anti-Xa activity and the antithrombotic activity in an ultra-low molecular weight heparin fraction.},
  author={Paul A Ockelford and Cedric J. Carter and Lesley Mitchell and Jack Hirsh},
  journal={Thrombosis research},
  year={1982},
  volume={28 3},
  pages={401-9}
}
The relationship between the in vivo antithrombotic effect of heparin and ex vivo anti-Xa activity has been investigated using an animal thrombosis model. Three low molecular weight heparins were compared with the standard heparin from which they were fractionated. All four heparins showed a dose-dependent antithrombotic effect enabling the relative antithrombotic and anti-Xa activities to be compared over a dosage range. A correlation between ex vivo anti-Xa heparin levels and antithrombotic… CONTINUE READING