Discordance between HbA1c and fructosamine: evidence for a glycosylation gap and its relation to diabetic nephropathy.

@article{Cohen2003DiscordanceBH,
  title={Discordance between HbA1c and fructosamine: evidence for a glycosylation gap and its relation to diabetic nephropathy.},
  author={Robert M. Cohen and Yancey R. Holmes and Thomas C. Chenier and Clinton H. Joiner},
  journal={Diabetes care},
  year={2003},
  volume={26 1},
  pages={163-7}
}
OBJECTIVE Discordances between HbA1c and other measures of glycemic control are common in clinical practice and remain unexplained. We developed a measure of discordance between HbA1c and fructosamine (FA) (glycosylated serum proteins) to conduct a systematic evaluation. We termed this the glycosylation gap (GG) and sought to determine its relationship to diabetic nephropathy. RESEARCH DESIGN AND METHODS Measurements of HbA1c and FA on the same sample in 153 people were used to calculate GG… CONTINUE READING