Discordance across several methods for drug susceptibility testing of drug-resistant Mycobacterium tuberculosis isolates in a single laboratory.

@article{Banu2014DiscordanceAS,
  title={Discordance across several methods for drug susceptibility testing of drug-resistant Mycobacterium tuberculosis isolates in a single laboratory.},
  author={Sayera Banu and S. M. Mazidur Rahman and Md. Siddiqur Rahman Khan and Sara Sabrina Ferdous and Shahriar Ahmed and J. Michael Gratz and Suzanne E. Stroup and Suporn Pholwat and Scott K. Heysell and Eric R Houpt},
  journal={Journal of clinical microbiology},
  year={2014},
  volume={52 1},
  pages={156-63}
}
Given the increases in drug-resistant tuberculosis, laboratory capacities for drug susceptibility testing are being scaled up worldwide. A laboratory must decide among several endorsed methodologies. We evaluated 87 Mycobacterium tuberculosis isolates for concordance of susceptibility results across six methods: the L-J proportion method, MGIT 960 SIRE AST, Gene/Xpert MTB/RIF, GenoType MTBDRplus line probe assay, MycoTB MIC plate, and a laboratory-developed mycobacteriophage quantitative PCR… CONTINUE READING
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