Discontinuing prophylactic transfusions used to prevent stroke in sickle cell disease.

  title={Discontinuing prophylactic transfusions used to prevent stroke in sickle cell disease.},
  author={Robert J. Adams and Donald Brambilla},
  journal={The New England journal of medicine},
  volume={353 26},
BACKGROUND Prophylactic transfusion prevents strokes in children with sickle cell anemia who have abnormalities on transcranial Doppler ultrasonographic examination. However, it is not known how long transfusion should be continued in these children. METHODS We studied children with sickle cell disease who had a high risk of stroke on the basis of a transcranial Doppler screening examination and who had received transfusions for 30 months or longer, during which time the Doppler readings… CONTINUE READING
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