Discontinuation of antihyperlipidemic drugs--do rates reported in clinical trials reflect rates in primary care settings?

@article{Andrade1995DiscontinuationOA,
  title={Discontinuation of antihyperlipidemic drugs--do rates reported in clinical trials reflect rates in primary care settings?},
  author={Susan E. Andrade and Alexander Muir Walker and Lois Gottlieb and Norman Kenneth Hollenberg and Marcia A. Testa and Gordon M Saperia and Richard Platt},
  journal={The New England journal of medicine},
  year={1995},
  volume={332 17},
  pages={1125-31}
}
BACKGROUND Discontinuation rates for drugs used to treat chronic conditions may affect the success of therapy. However, the discontinuation rates reported in clinical trials may not reflect those in primary care settings. METHODS We conducted a cohort study using computerized research files and medical records on 2369 new users of antihyperlipidemic therapy at two health maintenance organizations (HMOs) from 1988 through 1990. The rates of drug discontinuation in these primary care settings… CONTINUE READING
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