Disconnection of speech-relevant brain areas in persistent developmental stuttering

@article{Sommer2002DisconnectionOS,
  title={Disconnection of speech-relevant brain areas in persistent developmental stuttering},
  author={Martin Sommer and M. A. Koch and Walter Paulus and Cornelius Weiller and Christian B{\"u}chel},
  journal={The Lancet},
  year={2002},
  volume={360},
  pages={380-383}
}

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References

SHOWING 1-10 OF 30 REFERENCES

A PET study of the neural systems of stuttering

TLDR
Induced fluency decreased or eliminated the overactivity in most motor areas, and largely reversed the auditory-system underactivations and the deactivation of the speech production system, suggesting stuttering is a disorder affecting the multiple neural systems used for speaking.

Anomalous anatomy of speech–language areas in adults with persistent developmental stuttering

TLDR
These results provide the first evidence that anatomic anomalies within perisylvian speech–language areas may put an individual at risk for the development of stuttering.

Altered patterns of cerebral activity during speech and language production in developmental stuttering. An H2(15)O positron emission tomography study.

TLDR
Comparison of scans acquired during fluency versus dysfluency-evoking tasks suggested that during the production of stuttered speech, anterior forebrain regions are disproportionately active in stuttering subjects, while post-rolandic regions-which play a role in perception and decoding of sensory information-are relatively silent.

Brain correlates of stuttering and syllable production. A PET performance-correlation analysis.

To distinguish the neural systems of normal speech from those of stuttering, PET images of brain blood flow were probed (correlated voxel-wise) with per-trial speech-behaviour scores obtained during

Is Overt Stuttered Speech a Prerequisite for the Neural Activations Associated with Chronic Developmental Stuttering?

TLDR
Overt stuttering appears not to be a prerequisite for the prominent regional activations and deactivations associated with stuttering, and controls displayed fewer similarities between regional activation and deactivation during actual and imagined oral reading.

Single word reading in developmental stutterers and fluent speakers.

TLDR
A network including the left inferior frontal cortex and the right motor/premotor cortex, likely to be relevant in merging linguistic and affective prosody with articulation during fluent speech, thus appears to be partly dysfunctional in developmental stutterers.

Recovery from wernicke's aphasia: A positron emission tomographic study

TLDR
Increased left frontal and right perisylvian activity in patients with persisting destruction of Wernicke's area emphasizes redistribution of activity within the framework of a preexisting, parallel processing and bilateral network as the central mechanism in functional reorganization of the language system after stroke.

Functional organization of the auditory cortex is different in stutterers and fluent speakers

TLDR
The altered inter-hemispheric balance in stutterers was affected by speech production, due to changes in the left auditory cortical representation, and more severely by self-paced than accompanied speech.

Language function, foot of the third frontal gyrus, and rolandic operculum.

TLDR
It is concluded that overlapping lesions of these two areas play an important role in the development of persistent Broca's aphasia and that each ofThese two areas may be responsible for different components of the speech production: work-finding difficulties being associated with lesions of posterior F3 and articulatory disorders with lesions the Rolandic operculum.