Discoidin domain receptors: unique receptor tyrosine kinases in collagen-mediated signaling.

  title={Discoidin domain receptors: unique receptor tyrosine kinases in collagen-mediated signaling.},
  author={Hsueh-Liang Fu and Rajeshwari R. Valiathan and Richard T Arkwright and Anjum Sohail and Cosmin Mihai and Malika Kumarasiri and Kiran V Mahasenan and Shahriar Mobashery and Paul Huang and G Agarwal and Rafael Fridman},
  journal={The Journal of biological chemistry},
  volume={288 11},
The discoidin domain receptors (DDRs) are receptor tyrosine kinases that recognize collagens as their ligands. DDRs display unique structural features and distinctive activation kinetics, which set them apart from other members of the kinase superfamily. DDRs regulate cell-collagen interactions in normal and pathological conditions and thus are emerging as major sensors of collagen matrices and potential novel therapeutic targets. New structural and biological information has shed light on the… CONTINUE READING
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