Discoidin domain receptor functions in physiological and pathological conditions.

@article{Leitinger2014DiscoidinDR,
  title={Discoidin domain receptor functions in physiological and pathological conditions.},
  author={Birgit Leitinger},
  journal={International review of cell and molecular biology},
  year={2014},
  volume={310},
  pages={39-87}
}
The discoidin domain receptors, DDR1 and DDR2, are nonintegrin collagen receptors that are members of the receptor tyrosine kinase family. Both DDRs bind a number of different collagen types and play important roles in embryo development. Dysregulated DDR function is associated with progression of various human diseases, including fibrosis, arthritis, and cancer. By interacting with key components of the extracellular matrix and displaying distinct activation kinetics, the DDRs form a unique… CONTINUE READING