Discoidin domain receptor 2 mediates tumor cell cycle arrest induced by fibrillar collagen.

Abstract

During malignant invasion tumor cells establish contact with extracellular matrix proteins, including fibrillar collagen. In addition to providing a physical barrier against invasion, fibrillar collagen also restricts cell proliferation. It has been assumed that the growth regulatory activity of fibrillar collagen is the result of an indirect restrictive… (More)

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