Discoidin domain receptor 1 is a novel transcriptional target of ZEB1 in breast epithelial cells undergoing H-Ras-induced epithelial to mesenchymal transition.

@article{Koh2015DiscoidinDR,
  title={Discoidin domain receptor 1 is a novel transcriptional target of ZEB1 in breast epithelial cells undergoing H-Ras-induced epithelial to mesenchymal transition.},
  author={Minsoo Koh and Yunjung Woo and Rajeshwari R. Valiathan and Hae Yoen Jung and So-Yeon Park and Yong Nyun Kim and Hyoun Chull Kim and Rafael Fridman and Aree Moon},
  journal={International journal of cancer},
  year={2015},
  volume={136 6},
  pages={
          E508-20
        }
}
The epithelial-to-mesenchymal transition (EMT) process allows carcinoma cells to dissociate from the primary tumor thereby facilitating tumor cell invasion and metastasis. Ras-dependent hyperactive signaling is commonly associated with tumorigenesis, invasion, EMT, and metastasis. However, the downstream effectors by which Ras regulates EMT remain ill defined. In this study, we show that the H-Ras pathway leads to mesenchymal-like phenotypic changes in human breast epithelial cells by… CONTINUE READING
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