Discoidin domain receptor 1 is a major mediator of inflammation and fibrosis in obstructive nephropathy.

@article{Guerrot2011DiscoidinDR,
  title={Discoidin domain receptor 1 is a major mediator of inflammation and fibrosis in obstructive nephropathy.},
  author={Dominique Guerrot and Monique Kerroch and Sandrine Placier and Sophie Vandermeersch and Claire Trivin and Mouna Mael-ainin and Christos Chatziantoniou and Jean-Claude Dussaule},
  journal={The American journal of pathology},
  year={2011},
  volume={179 1},
  pages={
          83-91
        }
}
The interactions between tubulointerstitial infiltrating cells and the extracellular matrix play an important role in regulating renal fibrosis. Discoidin domain receptor 1 (DDR1) is a nonintegrin tyrosine kinase receptor for collagen implicated in cell adhesion, proliferation, and extracellular matrix remodeling. We have previously demonstrated that transgenic mice lacking DDR1 are protected from hypertension-associated renal fibrosis. The purpose of this study was to determine the role of… CONTINUE READING
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