Disclosure of the mycobacterial outer membrane: cryo-electron tomography and vitreous sections reveal the lipid bilayer structure.

@article{Hoffmann2008DisclosureOT,
  title={Disclosure of the mycobacterial outer membrane: cryo-electron tomography and vitreous sections reveal the lipid bilayer structure.},
  author={Christian Hoffmann and Andrew Leis and Michael Niederweis and J{\"u}rgen M Plitzko and Harald Engelhardt},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 10},
  pages={3963-7}
}
The cell walls of mycobacteria form an exceptional permeability barrier, and they are essential for virulence. They contain extractable lipids and long-chain mycolic acids that are covalently linked to peptidoglycan via an arabinogalactan network. The lipids were thought to form an asymmetrical bilayer of considerable thickness, but this could never be proven directly by microscopy or other means. Cryo-electron tomography of unperturbed or detergent-treated cells of Mycobacterium smegmatis… CONTINUE READING

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