Disclosure of APOE genotype for risk of Alzheimer's disease.

@article{Green2009DisclosureOA,
  title={Disclosure of APOE genotype for risk of Alzheimer's disease.},
  author={Robert C. Green and Jeffrey Scott Roberts and L. Adrienne Cupples and Norman Relkin and Peter John Whitehouse and Tamsen Brown and Susan Larusse Eckert and Melissa Barber Butson and Adele D. Sadovnick and Kimberly A. Quaid and Clara C. Chen and Robert Cook-Deegan and Lindsay A. Farrer},
  journal={The New England journal of medicine},
  year={2009},
  volume={361 3},
  pages={
          245-54
        }
}
BACKGROUND The apolipoprotein E (APOE) genotype provides information on the risk of Alzheimer's disease, but the genotyping of patients and their family members has been discouraged. We examined the effect of genotype disclosure in a prospective, randomized, controlled trial. METHODS We randomly assigned 162 asymptomatic adults who had a parent with Alzheimer's disease to receive the results of their own APOE genotyping (disclosure group) or not to receive such results (nondisclosure group… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 39 REFERENCES